Biology And Biomedical Sciences BIOL 2960 Lecture Notes - Lecture 6: Ribose, Photosynthetic Reaction Centre, Electrochemical Gradient

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Tca cycle (citric acid cycle) is in the mitochondria. Purpose: 1 substrate level phosphorylation, but mainly to harvest high-energy electrons from carbon fuels. There are important relationships between the major metabolic pathways of the cell: Pathways responsible for the synthesis and degradation of amino acids, nucleic acids, carbohydrates, and lipids are often reversible and connected to each other. Chemiosmosis: mitochondria are isolated from cells and placed in a medium at ph 8. This results in a low h+ concentration both outside and inside the organelles. The mitochondria are moved to an acidic medium (ph 4, high h+ concentration) H+ movement into mitochondria drives the synthesis of atp in the absence of continuous electron transport. Nadh -> high energy electron -> h+ gradient -> atp. Oxygen is the final electron acceptor in the electron transport chain which is why oxygen is needed to perform the electron transport chain.

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