ANAT 261 Lecture Notes - Lecture 3: Laminin, Fibronectin, Proteoglycan

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tobiusmcf

24 Nov 2021

School

McGill University

Department

Anatomy & Cell Biology

Course

ANAT 261

Professor

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Document Summary

Proteoglycan: protein (cid:8869) 501 . sugar; (cid:8869) found in bm in collagen (cid:8869) gags change - dependamment of the function. It : reticular fibers; synthesized by epi . bismil. They are negatively charged attracts water and gives s mushiness us. 90% protein their function ? (cid:8869) ex : laminin. Bm ex : nidoyen - i ex : fibronectin. Adhesive ; binds pm of epiccells heparan sulfate to. D structural attunement between et & ct (of the dermis: compartmentalization ; isolates epi . cells from the dermis. Important regulates movement of molecules thanks to ionic charge in kidney: maintenance of polarity for directionality of cells} most basal part of. Necessary epithelium knows the bm (cid:15482) grows in right direction. For regeneration after trauma (cid:15482) bm scaffolds new fibrous tissue to heal. Junctional complexes (cid:8869) provide adhesion i communication between cells ; epi cells adhere strongly to each other & basal laminae ibm. Tight i occludlns (cid:15482) forms seal between cells.

Related Questions

What do the proteoglycan and collagencomponents of cartilage contribute to connective tissue?(Explainthe mechanical reason the gel-like aggregates of proteoglycan areimportant to the knee)

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Qs. 3) Maligant cancer cells that have entered the bloodstream can imitate lymphocytes in exiting the bloodstream and entering underlying issues in the process of metastasis. This âlymphocyte mimicryâ can be summarized asâ¦.

A) An initial cadherin-dependent rolling followed by an integrin-dependent adhesion and emigration

B) An initial cadherin-dependent rolling followed by an I-CAM-dependent adhesion and emigration

C) An initial cadherin-dependent rolling followed by a selectin-dependent adhesion and emigration

D) An initial selectin-dependent rolling followed by a cadherin-dependent adhesion and emigration

E) An initial selectin-dependent rolling followed by an I-CAM-dependent adhesion and emigration

Qs. 4) Type IV collagen molecules can interact at their C-termini to form dimers and at their N-termini to form tetramers. What category do you think this type of collagen belongs to?

A) Fibrillar

B) Fibril-associated

C) Network-forming

D) Proteoglycan core

E) Anchorage fibril

Qs. 5) Which components of the extracellcular matrix are mostly responsible for its ability to resist compressive and tensile forces, respectivally?

A) Collagens and glycoproteins

B) Glycoproteins and collagens

C) Glycosaminoglycans and glycoproteins

D) Glycosaminoglycans and collagens

E) Collagens and glycosaminoglycans

Qs. 6) the size distribution of exons coding for collagen helical domains in various vertebrates reveals a unique pattern. This pattern provides clues to the evolutionary history of the genes encoding fibrillar collagen a chains. What is this pattern?

A) The length of most exons is a multiple of 100 nucleotides

B) Most exons code for 54, or a multiple of 54, Gly-X-Y repeats.

C) The length of most exons is a multiple of 30 nucleotides

D) Most exons code for 6, or a multiple of 6, Gly-X-Y repeats

E) None of the above