BIOL 252 Lecture Notes - Lecture 1: Antigen-Presenting Cell, Major Histocompatibility Complex, Lymph Node
Document Summary
Form the bridge between innate and adaptive immune responses. They are able to take in antigens and process them. They go to closest draining lymph node where they activate your b and t cells or your lymphocytes. They will reside in peripheral tissue, and when activated they go via the lymph vessels, into the lymph nodes. In the lymph nodes, they will activate the lymphocytes (naive t cells) which will then help activate b cells. Major histocompatibility complex (method of activation in lymph nodes) Mhc -1: expressed in all nucleated cells, activates cd8+ cells. A virus is processed, ends up in the endoplasmic reticulum, gets loaded onto one of the mhc -1 molecules, then travel via secretary system to the plasma membrane. At the plasma membrane, they can activate cd8 + t cells, which are cytotoxic cells. Able to endocytosis exogenous antigen, in an endosome it is cleaved and loaded onto a mhc class two.
