Biology 3316A/B Lecture Notes - Lecture 13: Smoothened, Hedgehog Signaling Pathway, Proteasome
Document Summary
High levels of cylopamine - alkaloid: blocking hog signal by interacting with smoothen, pathway is shut down. Problem with the development of the cns: eyes usually form in the forebrain, brain has not formed left and right, everything is in the middle. It is a proteosome that allows for transcription to be stopped. Patched - 12 membrane receptor: will bind to hog. When there is no hog present: patch will negatively regulate smoothened (smo, part of the frzd family gpcr, we don"t know what the ligand is. Smoothen never leaves the cell: the only time you see smoothen on the membrane is when hog is present. We have 3 hogs: expressed spatially and temporally: sonic determines cns. Indian - determines your height - works on bone formation- after puberty the zones will not respond to the signal: desert. Smo smoothened: a member of the frizzled family (no ligand)
