Medical Sciences 250ab Chapter Notes - Chapter Exercise: Polymerization, Fluorophore, Aminoglycoside
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One approach would be labelling the protein with a fluorophore and if after washing away, fluorescence is still left, we can confirm adherence. You could use this protein to produce antibodies. Then incubate the bacteria with the antibodies and if the antibodies bind to the protein it will no longer adhere. Or: add the isolated protein, if it binds to the receptor, the bacteria will no longer be able to adhere with the protein attached to it. Invasion serves to hide the pathogen from the immune system. They are protected from major attacks of the immune system. Penicillins and aminoglycosides cannot penetrate human cells, so intracellular pathogens are protected from that. Not all are invasive, some are completely invasive, some are only partly invasive, some are entirely non-invasive. The actin cytoskeleton/polymerisation creates a lot more force, allowing it to penetrate neighbouring cells. Generally, flagella allow faster movement but lack force that actin polymerisation produced.