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Biochemistry 2280A Lecture Notes - Lecture 24: Xeroderma Pigmentosum, Basal Lamina, Metastasis

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pingu70
19 Mar 2022
School
Western University
Department
Biochemistry
Course
Biochemistry 2280A
Professor
Dr. Michael Boffa, Dr. Derek Mc Lachlin, and Dr. Chris Brandl

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Document Summary

Strikes victims of all ages, and is becoming more prevalent as the population ages: characterized by genetic and biochemical defects, but these can provide opportunities for finding cures. Tumor types in cancer: benign: encapsulated with fibrous connective tissue, cannot spread from primary location. Can surgically remove, making it less severe: malignant: not encapsulated, tendency to spread to other areas from primary location. Susceptibility to cancer can be inherited: ex. Retinoblastoma, xeroderma pigmentosa, breast/prostate/ovarian/intestine: dna damaging agents cause cancer, radiation (uv, x-rays, chemical mutagens (benzene) Single most preventable cause: smoking: 30% of all cancers attributed to smoking (90% of lung cancer, cigarette smoke contains 69 chemicals known to cause cancer, arsenic - rat poison, benzene - mutagen. Cancer cells don"t follow these and keep dividing, even with damages. Types of cancer-causing genes: oncogenes: mutant form of normal gene whose presence causes cancer, act dominantly (gain of function, overtakes properties of other genes, making cell divide faster.

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Related Questions

Malignant cells are not always metastatic however, cells that have metastasized are considered malignant. How do these two definitions differ?

Malignant and metastatic cells both impair body function but metastatic cells are malignant cells that have also spread to other places in the body.

Malignant and metastatic cells both impair body function but malignant cells are metastatic cells that have also spread to other places in the body.

Malignant and metastatic cells both impair body function but metastatic cells are benign cells that have also spread to other places in the body.

Fully explain the difference between a benign tumor and a malignant tumor. Include a description of metastasis in your answer. List the four classes of malignant cancers telling the type of cells that give rise to each and where in the body it may cause cancer.

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