Lecture : Thyroid Eye Disease

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10 Jun 2022
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Closely correlating with graves" disease, patients with ted have been found to have elevated levels of antibodies against thyroid-stimulating hormone (tsh) receptors, which are expressed in orbital fat and connective tissue. Studies also attribute increased fibroblast activity as well as the accumulation of collagen and hyaluronic acid to the enlargement and fibrosis of the extraocular muscles. Other important symptoms to ask in the history include red eye, blurred vision (due to incomplete eyelid closure) and sensation of pressure. Patients may also present with systemic signs of thyroid disease, such as pretibial myxoedema, goitre and acropachy. Typical clinical findings in thyroid eye disease include: Diplopia due to restriction of extraocular muscles, most commonly inferior rectus. In a small portion of patients, the enlarged muscles and fat can press on the optic nerve, resulting in compressive optic neuropathy. Patients report reduced visual acuity, colour vision and contrast sensitivity. If this is not treated urgently, it can be sight-threatening.

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