BIO 360 Chapter Notes - Chapter 12: Adenylyl Cyclase, Protein Kinase A, Protein Kinase
Document Summary
Large # of gpcrs mediate effect via camp. Human genome encodes 1000 gpcr "s able to mediate multiple signals due to localization of. Pka localized to particular structures by anchoring protein. Different anchors are expressed in different cell types to determine the downstream effect of camp. C- protein-coupled signaling a" helical integral membrane proteins. Heterotrimetric ( a- by) membrane associated proteins bind gtp. Mediate signal transduction from gpcrs to other target proteins. Hormone in adrenal glands (pair of organs on kidneys) Binding receptors in muscle / liver cells breakdown glycogen. Binding receptors in adipose cells induces lipid hydrolysis. Binding receptors in heart cells heart rate. Activation of a few gpcrs leads to activation of few adenylyl cyclase enzymes. Active adenylyl cyclase enzymes makes 7 camp molecules ; activating several pka enzymes. Tens of thousands of glucose molecules are released. Self - inactivation mediates g- protein signaling desensitization.
