PHARMACOLOGY Lecture Notes - Lecture 1: Datura Stramonium, Hyoscyamus Niger, Neuromuscular-Blocking Drug
17 Oct 2022
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Conventionally the term anticholinergic drugs" is restricted to those which block actions of ach on autonomic effectors and in the cns exerted through muscarinic receptors. Though nicotinic receptor antagonists also block certain actions of ach, they are generally referred to as ganglion blockers" and neuromuscular blockers". It is highly selective for muscarinic receptors,but some of its synthetic substitutes do possess significant nicotinic blocking property in addition. The natural alkaloids are found in plants of the solanaceae family: atropine in. Atropa belladonna and datura stramonium, hyoscine in hyoscyamus niger. The levo-isomers are much more active than the dextroisomers. The actions of atropine can be largely predicted from knowledge of para(cid:2)sympathetic responses. Prominent effects are seen in organs which normally receive strong parasympathetic tone. It blocks all subtypes of muscarinic receptors: cns. Hyoscine differs from atropine in producing depressant (drowsiness, amnesia, fatigue) effects at low doses: cvs. Heart the most prominent effect of atropine is tachycardia.
