NURS 2050 Lecture Notes - Beta Blocker, Acetylcholinesterase Inhibitor, Muscarinic Antagonist
11 Apr 2013
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Atropine- muscarinic antagonist- blocks the action of acetylcholine @ muscarinic receptors (competitive) para + sweat blocker. Parasympatholytic: antimuscarinic- blocks at muscarinic, anticholinergic blocks ach. At therapeutic doses it will be selective for muscarinic receptors. Higher doses will produce blockade at nicotinic receptors too. Therapeutic uses (atropine: preanesthetic medication, eye disorders, bradycardia, intestinal hypertonicity/ hypermotility, muscarinic agonist poisoning, peptic ulcer disease, athma. Blurred vision physostigmine & neostigmine reversible cholinesterase inhibitors. Prevent ach breakdown by inhibiting acetylcholinersterases (or cholinesterase) Can have effects at all cholinergic junctions- nonselective as it can inhibit all enzymes. Irreversible prolonged effects a source of poisoning. Neuromuscular blocking (nmb) agents: prevent ach from activating nicotinic m receptors on skeletal muscles. Mechanism of action of nmbs: nondepolarizing neuromuscular blocker (bind competitively) (norcuron , depolarizing neuromuscular blocker (used in the icu for incubation, surgery) Mimic ach at nmj: succinylcholine (sole ultra-short acting agent) Depolarizing agent succinylcholine (mimics ach: turbocurarine, pancuronium (pavulon ),rocuronium (zemuron ), vecuronium.
