CAS PS 333 Lecture Notes - Neuroglia, Enkephalin, Cannabinoid
21 Oct 2022
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Synaptic recycling of the nt back up to the cells. Nts can"t be left in the synaptic cleft or their activity will never end. Transporters on the presynaptic cell or nearby glial cells can recycle nt. Alternatively, enzymes in the synapse can break down the nt there. Nt- chemicals released by brain cells that affect neighboring cells. Classical: released by ap: acts at synapse where released, allows signal from neuron to neuron. Neuromodulators: alter effectiveness of signal transmission released at various times, can act more distantly. Types of neuromodulators: histamine (sleep and alergies, adenosine (sleep, cannabinoids, soluble gases (co and no) Diffuses out of cell and may activate adjacent neurons. Receptors- proteins on cell surfaces or within walls. Ligand- molecule that binds to receptor with some selectivity (activate or block: drugs, nts, and other molecules. Transmitter gated ion channels: metabotropic (slower, indirect effects) G protein once activated goes on to produce other effects.
