MEDICAL TECHNOLOGY Lecture Notes - Lecture 1: Human Leukocyte Antigen, Major Histocompatibility Complex, Artificial Heart Valve
Document Summary
A foreign substance that has the ability to bind to an antibody. Immunogenic (aka antigenic): capable of stimulating an immune response. Not all antigens are immunogenic (they are called membrane response) not stimulating ab production contain surface membrane structures that are recognized by the immune system as. : bind paratope of ab: not all membrane surfaces can act as epitopes/antigenic determinants, only prominent determinants are recognized. Influence survival or rejection of transplanted organs (graft vs host disease) Wbcs gvhd (graft vs host disease: autoantigens. Abo blood group result to hemolytic transfusion reaction. Highly stimulating immune response: chemical nature of antigens, proteins: excellent antigens due to high. Systemic polymer: teflon, nylon non immunogenic (not a natural product) Used in making artificial heart valve, elbow replacement cannot be rejected by the body"s immune system. Has a simple structure: physical nature of antigens. Foreigness: the more foreign an antigen is, the more immunogenic it is.