BSCI170 Lecture Notes - Edward Tatum, George Beadle, Alkaptonuria
Document Summary
Converting genetic information stored in dna into rna. Genes and proteins: experiments over many years suggested that a gene code for and represents an individual protein, alkaptonuria, black urine (urine turns black when exposed to air) If you had one baby with it, it was likely your next baby would - suggests genetic. 1902: inborn errors of metabolism: george wells beadle and edward lawrie tatum, 1941: one gene-one enzyme hypothesis, nobel prize in 1958 for their discovery that genes act by regulating definite chemical events. Remember the central dogma: genetic information flows through the cell. Copying dna into rna: transcription: rna synthesis under the direction of a dna template, rna is a faithful copy (transcript) of the dna, we will focus on rna that codes for protein, messenger rna (mrna) Transcription: basic mechanism is similar between prokaryotes and eukaryotes, divided into three stages, initiation, elongation, termination, same stages seen in replication.
