NURS 14 Lecture Notes - Lecture 5: Herpes Simplex Virus, Innate Immune System, Autophagy
Document Summary
The herpes simplex virus (hsv) is a highly infectious virus that causes a range of diseases in humans, including cold sores, genital herpes, and encephalitis. Hsv is able to evade the host immune system and establish long-term infections is by manipulating the host cell"s death pathways. Hsv is able to inhibit apoptosis through the expression of several viral proteins, such as icp0, icp4, and icp22, which interact with and inhibit the activity of key proteins in the apoptosis pathway, such as caspases and bcl-2. Another way in which hsv manipulates the host cell"s death pathways is through the induction of necrosis, which is a form of non-programmed cell death that is characterized by the rapid and explosive death of cells. Hsv is able to induce necrosis through the expression of viral proteins, such as vp22 and vp16, which interact with and activate proinflammatory cytokines, such as tnf-alpha and il-1.
