Question

Synergism in transcriptional regulation occurs when two transcription factors have a much greater effect when they are both active than would be predicted if one added their individual effects.
A. True
B. False

The N-terminal region of histones extends from nucleosomes. These histone tails can be covalently modified to signal that a gene in the region should be transcribed. What is the covalent modification?
A. Adding a poly A tail
B. Adding acetyl groups
C. Removing acetyl groups
D. Removing a poly A tail

You are studying how the estrogen receptor regulates expression of a particular gene in breast cancer cells grown in a test tube. You examine cells grown in the presence of estrogenic hormones. Using various biochemical techniques, you find that the activated estrogen receptor [i.e., with hormone(s) bound] binds to cis regulatory sequences in the gene of interest and recruits (physically interacts with) a protein that has histone deacetylase activity. Based on this information, do you predict that estrogen hormones induce transcription, have no effect on transcription, or suppress transcription of the target gene?
A. No effect
B. Induce
C. Suppress