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  1. What is the normal role of Aquaporin-2 in the kidney?
  2. Why is phosphorylation important in aquaporin trafficking?

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Collen Von
Collen VonLv2
28 Sep 2019

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Related questions

Aquaporin expression changes with water deficit.

Perhaps by using Darcy's Law: Darcy’s Law: Jj = -Lpath ∆Ψw / ∆x

Where: L = hydraulic conductivity (how permeable is the pathway)

∆Ψw = water potential gradient

∆x = distance in the pathway

• Describe what aquaporins are and how the expression of aquaporins would alter the flow of water through tissues.

• As the soil dries out, how does ∆Ψw from the soil to the root change?

• What could the plant do to maintain ∆Ψw and the utility of the aquaporins (look at the equation and recognize that aquaporins increase L)?

(Be sure to include in the answer: Describes aquaporin structure, function, and places them in biological context that provides information on their influence on water flux, Establishes changes in ∆Ψ as soil dries, Describes cell level changes that maintain favorable water gradients)

In 2003, Peter Agre was awarded the Nobel Prize in chemistry for working out the structure and function of aquaporins. Since then there has been much interest in the development of synthetic membranes that would contain aquaporins and be used to economically provide fresh drinking water, water for space travel, and water for industrial uses. Here is an example of a project that was funded by the EPA - http://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/8895.

Questions:

1. Describe your understanding of the type of molecule an aquaporin is and how it functions normally in the membrane of a cell.

2. How might it remove salts and contaminates from water if it is placed in a synthetic membrane that mimics (biomimetic) a cell membrane.

3. How useful and what humanitarian projects might an aquaporin biomimetric membrane be useful for (give some good examples)? Do you think it might be useful in the United States?

Aquaporin expression changes with water deficit.

Perhaps by using Darcy's Law: Darcy’s Law: Jj = -Lpath DYw / ∆x

Where: L = hydraulic conductivity (how permeable is the pathway)

DYw = water potential gradient

Dx = distance in the pathway

• Describe what aquaporins are and how the expression of aquaporins would alter the flow of water through tissues.

• As the soil dries out, how does DYw from the soil to the root change?

• What could the plant do to maintain DYw and the utility of the aquaporins (look at the equation and recognize that aquaporins increase L)?

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