What is meant by a drug that has a narrow therapeutic window andhow does that impact dosing? Describe the therapeutic index interms of , LD50, ED50
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QUESTION 1
A partial agonist would:
a) Have lower efficacy than a full agonist | ||
b) Would be less effective at stabilizing the active form of a receptor than a full agonist | ||
c) Would have greater intrinsic activity than an antagonist | ||
d) All of the above |
QUESTION 2
The presence of spare receptors means that a drug would:
a) Would have its potency unchanged by low levels of noncompetitive antagonists | ||
b) Still maintain its maximal efficacy at low concentrations of noncompetitive antagonists | ||
c) Achieve its maximal response without occupying all available receptors | ||
d) A and C | ||
e) B and C |
QUESTION 3
A competitive antagonist would:
a) Increase drug potency | ||
b) Decrease drug efficacy | ||
c) Decrease drug potency | ||
d) Increase drug efficacy |
QUESTION 4
pH trapping explains:
a) Why drugs will break down when exposed to acidic conditions | ||
b) Why drugs do not diffuse back and forth between the kidneys and circulation | ||
c) Why drugs are attracted to adipose tissue | ||
d) How drugs are metabolized |
QUESTION 5
An ideal drug would have:
a) High potency, high efficacy, and a large therapeutic index | ||
b) High potency, high efficacy, and a small therapeutic index | ||
c) A high ED50, high efficacy, and a large therapeutic index | ||
d) High intrinsic activity, low affinity, and a low LD50 |
QUESTION 6
Which of the following is most likely to cross the membrane of a cell?
a) A nonpolar compound | ||
b) A polar compound | ||
c) A charged compound | ||
d) A large compound |
QUESTION 7
Which is not a pharmacodynamic process?
a) Absorption | ||
b) Excretion | ||
c) Metabolism | ||
d) Digestion |
QUESTION 8
A drug with a low Vd would:
a) Be less likely to bind to plasma proteins | ||
b) Have a higher rate of clearance | ||
c) Disseminate widely through tissues | ||
d) Remain primarily within the circulation |
QUESTION 9
First-pass metabolism does not occur through which method of drug administration?
a) Intramuscular | ||
b) Intravenous | ||
c) Transdermal | ||
d) Enteral |
QUESTION 10
A drug with greater efficacy would:
a) Have a greater maximal response | ||
b) Require a lower dose to reach its maximal effect | ||
c) Be less toxic | ||
d) All of the above |