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Cancer is a disease related to uncontrolled cell division. Investigate two known causes for these rapidly dividing cells and use this knowledge to invent a drug that would inhibit the growth of cancer cells?

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Nelly Stracke
Nelly StrackeLv2
28 Sep 2019
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Related questions

Tumor cells often develop mutations that lead to the loss of mitochondria. However, tumor cells are still able to proliferate rapidly even in the presence of oxygen. (1) How is this possible? (2) How would a drug that inhibits hexokinase interfere with cancer growth? (3) Give 2 examples of how a drug could inhibit hexokinase. (4) How could normal cells survive?

5. Identify a factor that can stop cells from growing. Give anexample of how this factor affects cell growth
6. List two problems that growth causes for cell.
7. Why are chromosomes not visible in most cells except during celldovision?
8. Name two factors that help regulate the timing of the cellcycle
9. How do cancer cells differ from normal cells?

You are interested in studying the origins of cancer and join a research lab to do so. You find that many cancer cell lines have mutations in the gene DRG1. You further investigate the mutations to DRG1 and find that some of the cell lines have mutations that affect expression of DRG1, so that no DRG1 mRNA is made in these cells, while other cell lines have mutations that lead the cells to produce a non-functional DRG1 protein.

a) Is DRG1 a proto-oncogene or a tumor suppressor? Explain your reasoning.

b) Your labmates propose several hypotheses about the possible role for DRG1 in normal cells. For each hypothesis, state whether or not you think it makes sense and explain your reasoning. a. DRG1 normally acts to repair DNA damage. b. DRG1 is a receptor for a mitogen (a signaling molecule that promotes cell division)

c. DRG1 is a receptor for a signaling molecule that causes apoptosis (programmed cell death).

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