Histone proteins areamong the most highly conserved proteins in eukaryotes. Histone H4proteins from a pea and a cow, for example, differ in only 2 of 102amino acids. Comparison of the gene sequences shows many moredifferences at the nucleotide level, but only two of these changeencoded amino acids. These observations indicate that mutationsthat change amino acids must be selected against. Why do yousuppose that amino acid-altering mutations in histone genes aredeleterious?

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Nestor Rutherford
Nestor RutherfordLv2
28 Sep 2019

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