how is it that diffusion coefficients measured for lipids withinmembranes tend to be closer to that of free diffusion than thosemeasured for integral proteins in the same membrane?

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Jean KeelingLv2

28 Sep 2019

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Protein lateral motion is much slower than that of lipids because proteins are larger than lipids. Also, some membrane proteins can diffuse freely through the membrane, whereas others are bound or anchored to other protein structures in the membrane.

The diffusion coefficient for the membrane protein fibronectin is approximately 7.00Ã10-13 cm2/sec, whereas that for rhodopsin is about 3.00Ã10-9 cm2/sec.

A) Calculate the distance traversed (in nm) by each of these proteins in 55.0 msec.

Distance traversed by rhodopsin =_____

Distance traversed by fibronectin =_____

B) Determine the expected and actual ratio of the diffusion coefficients, and determine whether the size difference accounts for the difference in the diffusion coefficients (D).

(The Mr of rhodopsin and fibronectin are 40000 and 460000 Da respectively.)

Expected D(rhodopsin:fibronectin) =

Actual D(rhodopsin:fibronectin) =

Does the size difference account for the difference in diffusion coefficients in these two proteins?

All of the following are generally accepted as features of the fluid-mosaic model of membrane structure EXCEPT Question 116 options: A. asymmetrical arrangement of lipids. B. rapid diffusion of inorganic ions across the lipid bilayer C. rapid lateral diffusion of lipids. D. slow lateral diffusion of integral and peripheral proteins. E. infrequent transverse (flip-flop) movement of lipids from one face of the bilayer to the other.

1. What are the structural and functional units of a living organism? 2. What is the role of the cell membrane? 3. What is the cell membrane made of? 4. What does phospholipid bi-layer mean? 5. What are some functions of membrane proteins? 6. What are the two major groups of cell membrane proteins? How are they different? 7. Describe diffusion. 8. What does selectively permeable mean? 9. Does diffusion require energy from the cell? 10. What might restrict the movement of a molecule across a cell membrane? 11. In the video what are channel proteins are compared to? 12. What does gated channel mean? 13. Explain osmosis. 14. Explain isotonic. 15. Explain hypotonic. 16. Explain lysis of a cell. 17. Explain hypertonic. 18. How is facilitated diffusion different than regular diffusion? 19. Define active transport. 20. What does the sodium / potassium pump do for the cell?

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how is it that diffusion coefficients measured for lipids withinmembranes tend to be closer to that of free diffusion than thosemeasured for integral proteins in the same membrane?

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