10. The pyrimidine and purinebases are nitrogen containing compounds. What is the source ofnitrogen for these two ring systems? In most examples,the reaction to add nitrogen to the growing ring structure requiresan activation of a carbon atom. What is the commonmechanism used to carry out this activation? Be able to recognizethis when you see a reaction of this sort.
11. The activity ofribonucleotide reductase is regulated in two ways: its totalactivity is controlled and its substrate specificity is controlled.What are the metabolites that regulate both of theseactivities? How does the cell balance the concentrationof the various deoxynucleotide diphosphates? What is theprincipal similarity between ribonucleotide reductase and thenitrogenase complex?
10. The pyrimidine and purinebases are nitrogen containing compounds. What is the source ofnitrogen for these two ring systems? In most examples,the reaction to add nitrogen to the growing ring structure requiresan activation of a carbon atom. What is the commonmechanism used to carry out this activation? Be able to recognizethis when you see a reaction of this sort.
11. The activity ofribonucleotide reductase is regulated in two ways: its totalactivity is controlled and its substrate specificity is controlled.What are the metabolites that regulate both of theseactivities? How does the cell balance the concentrationof the various deoxynucleotide diphosphates? What is theprincipal similarity between ribonucleotide reductase and thenitrogenase complex?
