Comparing MHC I a-chain and b2-microglobulin (b2-MG) in a family of six, including mom, dad and two daughters and two sons:
1) Among the six family members, which pair is more likely to find similarity between the two for possible transplant, father/mother, mother/daughter, father/son, father/daughter, or siblings? Why?
2) Deficiency in b2-MG was reported in 2 siblings. How does the b2-MG deficiency affect their immune system?
3) Hypothetical question: if an individual had genetic alterations in MHC-I, resulting in deletion of HLA-B, C, E, F and G gene loci, leaving only HLA-A intact, what would you expect of the immune system in this individual and why? Would this individual have similar phenotype to the one seen with the deficiency in b2-MG?
Comparing MHC I a-chain and b2-microglobulin (b2-MG) in a family of six, including mom, dad and two daughters and two sons:
1) Among the six family members, which pair is more likely to find similarity between the two for possible transplant, father/mother, mother/daughter, father/son, father/daughter, or siblings? Why?
2) Deficiency in b2-MG was reported in 2 siblings. How does the b2-MG deficiency affect their immune system?
3) Hypothetical question: if an individual had genetic alterations in MHC-I, resulting in deletion of HLA-B, C, E, F and G gene loci, leaving only HLA-A intact, what would you expect of the immune system in this individual and why? Would this individual have similar phenotype to the one seen with the deficiency in b2-MG?
