In your own word, Compare the pathogenesis of visceral leishmaniasis with Chagas disease (be specific and answer in complete sentences).
Visceral leishmaniasis is transmitted through the bite of a female sand fly. The sand fly bites the human and injects the promastigote into the blood known as the infection stage. Next promastigotes are phagocytized by the macrophages and transform into amastigotes inside the macrophages. The amastigotes then multiply inside the cells and then is picked up by a sand fly biting the human infected where the amastigotes transform into promastigotes inside the gut of the fly and divide. The process starts all over.
Chagas disease starts with the triatomine bug biting a human and passing the metacyclic trypomastigotes through their feces into the bite wound known as the infection stage. Once inside the host they penetrate cells and turn into amastigotes where they multiply by binary fission. The intracellular amastigotes transform into trypomastigotes and burst the cell entering the blood stream or they can infect other cells and start the transformation to amastigotes all over. Once they enter the blood stream the trypomastigotes can be picked up by another triatomine bug when they bite the human. Once inside the gut of the bug they turn into epimastigotes and multiply before turning back in to metacyclic trypomastigotes. The process starts all over.
In your own word, Compare the pathogenesis of visceral leishmaniasis with Chagas disease (be specific and answer in complete sentences).
Visceral leishmaniasis is transmitted through the bite of a female sand fly. The sand fly bites the human and injects the promastigote into the blood known as the infection stage. Next promastigotes are phagocytized by the macrophages and transform into amastigotes inside the macrophages. The amastigotes then multiply inside the cells and then is picked up by a sand fly biting the human infected where the amastigotes transform into promastigotes inside the gut of the fly and divide. The process starts all over.
Chagas disease starts with the triatomine bug biting a human and passing the metacyclic trypomastigotes through their feces into the bite wound known as the infection stage. Once inside the host they penetrate cells and turn into amastigotes where they multiply by binary fission. The intracellular amastigotes transform into trypomastigotes and burst the cell entering the blood stream or they can infect other cells and start the transformation to amastigotes all over. Once they enter the blood stream the trypomastigotes can be picked up by another triatomine bug when they bite the human. Once inside the gut of the bug they turn into epimastigotes and multiply before turning back in to metacyclic trypomastigotes. The process starts all over.
