Cystic Fibrosis is an autosomal recessive disease which usually leads to death in the early to mid-20s. Carriers are not affected. The normal allele is F and the disease allele is f. You want to know how strong selection is against the disease allele, and set out to find its selection coefficient (s).
What are the relative fitness of the normal genotypes? (0.5 pt. each, no calculation needed)
ÏFF =
ÏFf =
You find the following data regarding the number of people affected by CF 30 years ago, and today, from genetic tests of US hospital patients. In both years, the sample size was of 1348 individuals chosen at random from the population. It is known that that the mean relative fitness of the 1987 population was 0.919.
Distribution
FF
Ff
ff
1987
661
566
121
2018
782
489
77
find the relative fitness of the disease genotype, and the selection coefficient of the disease allele. Show your work and round results to 2 significant figures :
Cystic Fibrosis is an autosomal recessive disease which usually leads to death in the early to mid-20s. Carriers are not affected. The normal allele is F and the disease allele is f. You want to know how strong selection is against the disease allele, and set out to find its selection coefficient (s).
What are the relative fitness of the normal genotypes? (0.5 pt. each, no calculation needed)
ÏFF =
ÏFf =
You find the following data regarding the number of people affected by CF 30 years ago, and today, from genetic tests of US hospital patients. In both years, the sample size was of 1348 individuals chosen at random from the population. It is known that that the mean relative fitness of the 1987 population was 0.919.
| Distribution | FF | Ff | ff |
| 1987 | 661 | 566 | 121 |
| 2018 | 782 | 489 | 77 |
find the relative fitness of the disease genotype, and the selection coefficient of the disease allele. Show your work and round results to 2 significant figures :
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Related questions
You find the following data regarding the number of people affected by CF 30 years ago, and today, from genetic tests of US hospital patients. In both years, the sample size was of 1348 individuals chosen at random from the population. It is known that that the mean relative fitness of the 1987 population was 0.919.
| Distribution | FF | Ff | ff |
| 1987 | 661 | 566 | 121 |
| 2018 | 782 | 489 | 77 |
From these data, calculate the following quantities. Show you work, and round results to 2 significant figures (0.5 pt. each). Hint: you donât need the Hardy-Weinberg formula here.
p (frequency of normal allele in 1987) =
q (frequency of disease allele in 1987) =
pâ (frequency of normal allele in 2018) =
qâ (frequency of disease allele in 2018) =
