Question

Sister chromatid segregation during anaphase isdependent on the cleavage of cohesin proteins that hold the sisterstogether. Predict what will happen to sister chromatid segregationin the following situations. Provide a short explanation for youranswer. [Note: assume the only form of securin available in thecell is the one indicated].

i) non-degradable securin:

ii) a securin mutant that cannot associate with separase: