Question

Sister chromatid segregation during anaphase is dependent on thecleavage of cohesin proteins that hold the sisters together.Predict what will happen to sister chromatid segregation in thefollowing situations. Provide a short explanation for your answer.[Note: assume the only form of securin available in the cell is theone indicated].

i) non-degradable securin:

ii) a securin mutant that cannot associate withseparase: