Question II. A biochemist determines the amino acidsequence of the entire light chain from a purified immunoglobulinproduced by a patient whose genome was completely sequenced. Fromthis sequence this scientist is able to establish [complete thesentence and assess each subsequent statement (11-19) as eitherfactually correct (= âtrueâ) or incorrect (= âfalseâ)]:
*note that the question says that the entire light chain wasdetermined and the genome was completely sequenced*
11. the class of immunoglobulin.
12. the light chain isotype.
13. whether the B cell that produced this antibody received T-cellhelp.
14. the specific variable gene fragment used to produce thischain.
15. the antigen specificity of the immunoglobulin.
16. the number of VDJ rearrangements needed to produce this lightchain.
17. the most frequent amino acid present in this light chain.
18. the most frequent amino acid most likely to be present in theassociated heavy chain.
19. which antigens cannot react with this immunoglobulin.
Question II. A biochemist determines the amino acidsequence of the entire light chain from a purified immunoglobulinproduced by a patient whose genome was completely sequenced. Fromthis sequence this scientist is able to establish [complete thesentence and assess each subsequent statement (11-19) as eitherfactually correct (= âtrueâ) or incorrect (= âfalseâ)]:
*note that the question says that the entire light chain wasdetermined and the genome was completely sequenced*
11. the class of immunoglobulin.
12. the light chain isotype.
13. whether the B cell that produced this antibody received T-cellhelp.
14. the specific variable gene fragment used to produce thischain.
15. the antigen specificity of the immunoglobulin.
16. the number of VDJ rearrangements needed to produce this lightchain.
17. the most frequent amino acid present in this light chain.
18. the most frequent amino acid most likely to be present in theassociated heavy chain.
19. which antigens cannot react with this immunoglobulin.
