Transport of glucose into an intestinal epithelial cell and then out into the bloodstream stops when the cells are exposed to the molecule ouabain, a Na+/K+ pump inhibitor. How does the Na+K+ ATPase contribute to glucose transport in these cells?

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Beverley SmithLv2

28 Sep 2019

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Q1. Both neurons and epithelial cells can sometimes be joined to neighboring cells via gap junctions
a. TRUE
b. FALSE

Q2. Which of the following transport proteins is important for maintaining the electrical gradient across the plasma membrane of a neuron?
a. Facilitated transport proteins
b. Voltage-gated Na⁺ channel
c. Na⁺/K⁺ ATPase
d. Na⁺/glucose symporter SGLT1

Q3. During an action potential, Na⁺ influx______ the membrane potential, and K⁺ efflux subsequently ______ the membrane potential.
a. Depolarizes; repolarizes
b. Hyperpolarizes; depolarizes
c. Repolarizes; depolarizes
d. Polarizes; hyperpolarizes

In addition to Ca2+ channels at SER membrane, muscle cells also have antiports at the plasma membrane that transport Ca2+ out to extracellular space and import Na+. Doctors use Ouabain and digitalis to treat patients with heart disease because they make the heart muscle contract stronger.
What would be the mechanism of the drug action? Do using high concentration of these two medicine would kill the patients? Why? (Hint: Ouabain and digitalis partially inhibit Na+-K+ pump.)

secondary active transport via Na+/K+/ATPase is used to absorb molecule X across gut epithelial cells. A drug that inhibits uptake of this molecule acts by selectively inhibiting the gut Na+/K+/ATPase. However, when high dosage of the drug is taken, it leads to systemic inhibition of all Na+/K+/ATPasw in the body of the animal.

a)Discuss the implications this has on the metabolic rate of the animal.

b) would this animal be more tolerant to high environmental temperatures before a high dosage of the drug, or after?

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Transport of glucose into an intestinal epithelial cell and then out into the bloodstream stops when the cells are exposed to the molecule ouabain, a Na+/K+ pump inhibitor. How does the Na+K+ ATPase contribute to glucose transport in these cells?

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