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Acetylcholine binds to a G-coupled protein receptor on the heart muscle to make the heart beat more slowly. It does so by stimulating the opening of K+ channels in the plasma membrane, which makes it more difficult to initiate and action potential. Describe the following on contraction of the heart.
A.) Addition of a drug that inhibits the GTPase activity of the Ga subunit.
B.) Mutations in the K+ channel that keep it closed all the tiem.
C.) A mutation that decreases the affinity of the (Beta gamma) complex of the G protein for the K+ channel.
Acetylcholine binds to a G-coupled protein receptor on the heart muscle to make the heart beat more slowly. It does so by stimulating the opening of K+ channels in the plasma membrane, which makes it more difficult to initiate and action potential. Describe the following on contraction of the heart.
A.) Addition of a drug that inhibits the GTPase activity of the Ga subunit.
B.) Mutations in the K+ channel that keep it closed all the tiem.
C.) A mutation that decreases the affinity of the (Beta gamma) complex of the G protein for the K+ channel.
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Tod ThielLv2
28 Sep 2019