Question

Sickle-cell anemia is an autosomal recessive disease, people with the disease have a ss genotype and people without the disease have a SS genotype. People who have the disease get very ill, but people who have only one copy of the recessive gene are actually protected from getting malaria (Ss heterozygote genotype). Which area of the world is the frequency of sickle cell anemia the highest? Why do you think this is true (related to heterozygote advantage)?

We talked about the disease hemophilia in reference to Sally. Based on what we know from the transmission pattern of the disease hemophilia (sex-linked recessive), why do you think it affects males more often than females?