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With reference to the antigens and antibodies present in ABO and RhD groups, explain which blood groups would be compatible for transfusion of red blood cells to a group B negative young female?

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Jarrod Robel
Jarrod RobelLv2
28 Sep 2019
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Related questions

6- With respect to a group A Rh (D) Positive patient who has been transfused with group O Rh (D) Negative red cells during the medical evacuation. What blood would you select for subsequent STAT transfusion?

* Group O Rh (D) Positive red cells.

* Group A Rh (D) Positive red cells.

* Group A Rh (D) Negative red cells

* Group O Rh (D) Positive red cells.

7- result of a direct anti-globulin test after a delayed transfusion reaction may be:

* Mixed-field.

* All of the alternatives.

* Positive with anti-C3d AHG but not anti-IgG AHG

* Positive.

* Negative.

8- in an emergency when there is insufficient time for normal pretransfusion testing which of the following should be issued without waiting for the results of a crossmatch?

* O Rh (D) Positive whole blood.

* O Rh (D) Positive packed cells.

* O Rh (D) Negative packed cells or modified whole blood.

* O Rh (D) Negative whole blood.

9- A patient presents for a 4 unit crossmatch. The patients blood group is AB Rh (D) Positive. You have the following units of blood available. 10 units of group O Rh (D) Positive, 6 units of group O Rh (D) Negative, 8 units of A Rh (D) Postive units. What units would you select for the crossmatch?

* 4 units of group O Neg.

* Ring the NHSBT and urgently request four units of AB Pos

* 2 units of O Pos and 2 units of O Neg.

* 4 units of A Pos.

10- You carry out an ABO and Rh grouping on a six cord bloods. Three of the cord bloods group as AB Rh (D) Positive. What steps would you take before reporting these results?

* Work out the statistical probability of such an occurrence, and if p<0.05 accept the results

* Do another ABO Rh check. If the same, report.

* Wash the cord blood cells in saline, and then repeat the groups.

* Check the maternal and paternal blood groups.

As we discussed in “lecture”, Rh is the most complex of the blood group types, involving at least 45 different antigens. The most clinically important antigen, D or RhO, is encoded by the gene RhD which is found on chromosome 1. Individuals that are Rh-positive have either one or two RhD genes, whereas the Rh-negative phenotype is caused by the absence of the RhD gene. (The antithetical allele d does not exist, however the letter "d" is used to indicate the D-negative phenotype). For the purpose of this homework, we will simplify things. Assume that the Rh blood group has only two alleles: the Rh-positive allele (D) and the Rh-negative allele (d). Erythroblastosis fetalis (EF) is a condition that causes the mother's red blood cells to attack those of the baby as if they were any foreign invaders. It is referred to as hemolytic anemia of the newborn. It is caused by anti-Rh antibodies from the mother which pass through the placenta and attack fetal blood cells that happen to be Rh-positive. Babies that are at risk for this condition are those with Rh-positive blood, whose mothers are Rh-negative (dd).

Consider a population under Hardy-Weinberg equilibrium, where the frequency of the Rh-negative allele, d, is 0.3. What is the frequency of crosses that could potentially produce children with erythroblastosis fetalis?

As we discussed in “lecture”, Rh is the most complex of theblood group types, involving at least 45 different antigens. Themost clinically important antigen, D orRhO, is encoded by the gene RhD whichis found on chromosome 1. Individuals that are Rh-positive haveeither one or two RhD genes, whereas the Rh-negativephenotype is caused by the absence of the RhD gene. (Theantithetical allele d does not exist, however the letter"d" is used to indicate the D-negative phenotype). For the purposeof this homework, we will simplify things. Assume that the Rh bloodgroup has only two alleles: the Rh-positive allele (D) andthe Rh-negative allele (d).

Erythroblastosis fetalis (EF) is a condition that causes themother's red blood cells to attack those of the baby as if theywere any foreign invaders. It is referred to as hemolytic anemia ofthe newborn. It is caused by anti-Rh antibodies from the motherwhich pass through the placenta and attack fetal blood cells thathappen to be Rh-positive. Babies that are at risk for thiscondition are those with Rh-positive blood, whose mothers areRh-negative (dd).

Side note: Here’s a current headline thataddresses this condition. It’s well worth a read!

http://www.cnn.com/2015/06/09/health/james-harrison-golden-arm-blood-rhesus/index.html

Consider a population under Hardy-Weinberg equilibrium, where thefrequency of the Rh-negative allele, d, is 0.3. What isthe frequency of crosses that could potentially produce childrenwith erythroblastosis fetalis?

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