Briefly summarize the palm, thumb, and finger domains of DNA polymerase, and explain how they contribute to replication. What is the role of the metal ions in the palm's activity? Please be as descriptive and as detailed as possible with this answer please.

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Nestor RutherfordLv2

28 Sep 2019

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Related questions

Explain what would happen to the DNA replication process if each of the proteins mentioned below was mutated and no longer functioned. Be sure to explain if one, both, or neither strand(s) of DNA would be affected. (DNA replication would stop is not a detailed answer)

DNA polymerase III â

Primase â

Ligase â

DNA polymerase I â

1. (10 points) What are the three enzymatic activities of DNA pol I? What is the role of each activity in the cell during DNA replication?

2. (10 points) DNA polymerase I, DNA ligase, and Topoisomerase I each catalyze the formation of phosphodiester bonds that are vital (directly or indirectly) to replication of DNA. What is the action of each of these enzymes in DNA replication and which part of replication do these enzymes participate in?

3. (10 points) The B-DNA helix undergoes a complete turn every 10.4 nucleotides, and the axial distance between nucleotides is 3.4 angstroms. DNA polymerase III has a rate of 1000 nucleotides per second. How fast does template DNA spin (expressed in revolutions per second) at an E. coli replication fork? What is the velocity of movement (in micrometers per second) of DNA polymerase III holoenzyme relative to the template?

4. (10 points) In contrast to DNA polymerase, RNA polymerase does not proofread and edit its products. Why does this absence of proofreading/correction in the synthesis of RNA not threaten the cellsâ viability? How would an enzyme using RNA as a template for DNA synthesis alter the rate of mutations for an organism?

Explain why the replication machinery is incapable of completely replicating the ends of the chromosomes. What is the practical effect of this? How do eukaryotic cells get around this problem?

Please be as detailed as possible please.