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What is more likely to have a detrimental effect on the phenotype: a 3 base pair deletion from the middle of the coding sequence of a gene, or a 8 base pair deletion from the same region of the gene? Why? Would the outcome be different if the deletions happened within the gene’s intron? Why?

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Nestor Rutherford
Nestor RutherfordLv2
28 Sep 2019

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Related questions

Consider each of the pairs of mutational events and decide which of each pair would likely have the greatest effect on an organism. Describe the effect of each and indicating which would have the greatest effect and your reasoning.

A) Substitution in the first nucleotide of a codon OR substitution in the third nucleotide of a codon

B) Deletion of six nucleotides in the coding region OR deletion of two nucleotides in the coding

region

C) Mutation in the intron of a gene OR mutation in the promoter of a gene

D) Name one other location (not mentioned above) that a mutation could occur that could affect

the protein product and explain how the mutation would have an effect.

Below is a partial mRNA sequence. Use it to answer the following questions.

5 - UGGUCGGCGAGAACGAAAGCGC - 3

The amino acids in the original partial sequence (N-term-...V-G-E-N-E-S...-C-term) have little to no impact on protein structure and function, with the exception of serine. Phosphorylation of the serine residue is required for normal function of the protein.

Given this information, which reversion mutation(s) in the gene would restore the normal function of the entire protein?
Select the four correct answers.

Deletion of 1 base-pair in the region of the valine codon
Insertion of 1 base-pair in the region of the valine codon
Deletion of 2 base-pairs in the region of the valine codon
Deletion of 5 base-pairs in the region of the valine codon
Insertion of 2 base-pairs in the region of the valine codon
Insertion of 4 base-pairs in the region of the valine codon

PART C IS THE PART I NEED HELP WITH PLEASE

Below is a partial mRNA sequence. Use it to answer the following questions.

5' - GCCGAUCGAACU - 3'

What is the correct reading frame for this mRNA?

5' - G | CCG | AUC | GAA | CU - 3'

If a single base-pair deletion occurred in the part of the gene that corresponds to the mRNA above and the resulting partial amino acid sequence was (N-term-...P-M-N...-C-term), which new partial mRNA sequence would be consistent with this change?

5' - G | CCG | AUG | AAC | U - 3'

Part C

The amino acids in the original partial sequence (N-term-...P-I-E...-C-term) have little to no impact on protein structure and function. However the amino acid sequence near the C-terminal end of the protein is required for normal function. Any amino acid changes in this region of the protein will result in a nonfunctional protein.

Given this information, which reversion mutation in the gene would restore the normal function of the protein?

Select all that apply.

Insertion of 2 base-pairs in the region of the proline codon

Deletion of 5 base-pairs in the region of the proline codon

Deletion of 2 base-pairs in the region of the proline codon

Deletion of 1 base-pair in the region of the proline codon

Insertion of 1 base-pair in the region of the proline codon

Insertion of 4 base-pairs in the region of the proline codon

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