The DNA segment shown below encodes a short peptide of 8 amino acids. Mutant forms of the gene encode the peptides shown below. Using the genetic code table and the figure showing amino acid structures provided at the back of this exam book, i) describe the exact mutations that must have occurred to give rise to each mutant (ie, the base pair change), ii) name the kind of mutation it is, and iii) explain how it leads to the mutant protein (assume each mutation is due to a single event).
5â â ATGCACGTAGGTAACACTGAGCCCTGACC â 3â
3â â TACGTGCATCCATTGTGACTCGGGACTGG â 5â
MetHisValGlyAsnThrGluPro
a) Mutant A: Met-His-Val-Asp-Asn-Thr-Glu-Pro
b) Mutant B: Met-His-Val-Gly-Lys-His
c. Mutant C: Met-His
d. Mutant D: Met-His-Val-Ala-Asn-Thr-Glu-Pro
e. Would mutant protein A likely be more similar in function to the wild type than mutant protein D, or less similar in function? Explain your answer.
The DNA segment shown below encodes a short peptide of 8 amino acids. Mutant forms of the gene encode the peptides shown below. Using the genetic code table and the figure showing amino acid structures provided at the back of this exam book, i) describe the exact mutations that must have occurred to give rise to each mutant (ie, the base pair change), ii) name the kind of mutation it is, and iii) explain how it leads to the mutant protein (assume each mutation is due to a single event).
5â â ATGCACGTAGGTAACACTGAGCCCTGACC â 3â
3â â TACGTGCATCCATTGTGACTCGGGACTGG â 5â
MetHisValGlyAsnThrGluPro
a) Mutant A: Met-His-Val-Asp-Asn-Thr-Glu-Pro
b) Mutant B: Met-His-Val-Gly-Lys-His
c. Mutant C: Met-His
d. Mutant D: Met-His-Val-Ala-Asn-Thr-Glu-Pro
e. Would mutant protein A likely be more similar in function to the wild type than mutant protein D, or less similar in function? Explain your answer.
