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blackwasp546Lv1
28 Sep 2019
BACKGROUND INFO:
For purposes of genetic counseling, you wish to determine thehemoglobin genotypes for a couple who both have family histories ofsickle cell disease.
Since hemoglobin S - Hb S - and hemoglobin A - Hb A - havedifferent net charges, if each is placed in an electrical field,the two types of hemoglobin proteins will migrate differently.(Note: Separation of molecules via this type of electrophoresis -unlike the gel electrophoresis considered in Unit 16 - depends onthe different net electrical charge (not the size â which isessentially the same for both hemoglobin proteins.)
QUESTION:
Will Hb A or Hb S move further toward the positive pole uponelectrophoresis? Hint: Recall the difference in charge due to thepoint mutation substituting valine for glutamate in Hb S.
BACKGROUND INFO:
For purposes of genetic counseling, you wish to determine thehemoglobin genotypes for a couple who both have family histories ofsickle cell disease.
Since hemoglobin S - Hb S - and hemoglobin A - Hb A - havedifferent net charges, if each is placed in an electrical field,the two types of hemoglobin proteins will migrate differently.(Note: Separation of molecules via this type of electrophoresis -unlike the gel electrophoresis considered in Unit 16 - depends onthe different net electrical charge (not the size â which isessentially the same for both hemoglobin proteins.)
QUESTION:
Will Hb A or Hb S move further toward the positive pole uponelectrophoresis? Hint: Recall the difference in charge due to thepoint mutation substituting valine for glutamate in Hb S.
For purposes of genetic counseling, you wish to determine thehemoglobin genotypes for a couple who both have family histories ofsickle cell disease.
Since hemoglobin S - Hb S - and hemoglobin A - Hb A - havedifferent net charges, if each is placed in an electrical field,the two types of hemoglobin proteins will migrate differently.(Note: Separation of molecules via this type of electrophoresis -unlike the gel electrophoresis considered in Unit 16 - depends onthe different net electrical charge (not the size â which isessentially the same for both hemoglobin proteins.)
QUESTION:
Will Hb A or Hb S move further toward the positive pole uponelectrophoresis? Hint: Recall the difference in charge due to thepoint mutation substituting valine for glutamate in Hb S.
Jean KeelingLv2
28 Sep 2019
