Question

I. ER Translocation of Secretory orTransmembrane Proteins:

1. During neural development,outgrowing nerve cell axons must interact with their cellularenvironment in order to determine correct organization andconnectivity. Cell adhesion molecules (CAMs) are prominentone passtransmembrane glycoproteins which mediate the signalingnecessary to ensure correct targeting of these nerve axons.

Question:

How is a cell adhesion transmembrane proteinsorted/translocated initially so that it will be inserted into theplasma membrane as a type I membrane protein?[Hint: Describethe specific steps that a type I transmembrane protein will gothrough in the RER for insertion into the membrane].