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1.What is the functional definition ofSTART? What is the molecular definition of START?

Cancer cells typically lose STARTcontrol. Explain how each of the following mutations, which arefound in some cancer cells, lead to a bypass of START controls:

(a) overexpression of cyclin D

(b) loss of Rb function

(c) loss of p16 function

(d) hyperactive E2F

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Deanna Hettinger
Deanna HettingerLv2
28 Sep 2019

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