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29 Sep 2019
4. It is possible to make some predictions about protein secondary structure based on the primary sequence. Consider the following amino acid sequence.
Ile-Ala-His-Thr-Tyr-Gly-Pro-Phe-Glu-Ala-Ala-Met-Cys-Lys-Trp-Glu-Ala-Gln-Pro-Asp-Gly-Met-Glu-Cys-Ala-Phe-His-Arg
(a) Where might B turns occur?
(b) Where might intrachain disulfide cross-linkages be formed?
(c) Assuming that this sequence is part of a larger globular protein, what is the probable location (exterior or interior of the protein) of the amino acid residues and explain your reasoning.
Asp Ile Thr Ala Gln Lys
4. It is possible to make some predictions about protein secondary structure based on the primary sequence. Consider the following amino acid sequence.
Ile-Ala-His-Thr-Tyr-Gly-Pro-Phe-Glu-Ala-Ala-Met-Cys-Lys-Trp-Glu-Ala-Gln-Pro-Asp-Gly-Met-Glu-Cys-Ala-Phe-His-Arg
(a) Where might B turns occur?
(b) Where might intrachain disulfide cross-linkages be formed?
(c) Assuming that this sequence is part of a larger globular protein, what is the probable location (exterior or interior of the protein) of the amino acid residues and explain your reasoning.
Asp Ile Thr Ala Gln Lys
Jamar FerryLv2
29 Sep 2019
Related textbook solutions
Related questions
For each polypeptide sequence, indicate what characteristic(s)an α helix or β sheet secondary structure
would have upon folding. The polar amino acids are italicizedand in bold.
| Polypeptide sequence | If folded into an α helix: | If folded into a β sheet: |
| Leu-gly-val-leu-gly-leu-phe-phe-gly-leu-met-trp-phe-phe-trp-ile | ||
| Ile-gln -lys-pro-thr-ser -asn-trp-asp -glu -ile-his -lys-arg -met-his | ||
| Thr -leu-asn-ile-ser-phe-gln -met-glu-leu-asp-val-ser-ile-arg -trp |
