When a genetic disease is present in a family, knowledge of gene transmission patterns can be used to calculate the probability of prospective parents' having affected offspring.A married couple finds out that each had an uncle with Tay-Sachs disease. The question is whether or not the man and woman are heterozygotes as they do not have the disease. If both are heterozygotes or carriers then there is a risk of having an affected child. The pedigree looks like this:
Pedigree can be found here: https://www.ncbi.nlm.nih.gov/books/NBK21257/
What is the probability that their first child will have Tay-Sachs (AR)? (show work)
What is the probability that their second child will have Fanconi Anemia?
What is the risk of an affected child if one of the parents is a carrier?
When a genetic disease is present in a family, knowledge of gene transmission patterns can be used to calculate the probability of prospective parents' having affected offspring.A married couple finds out that each had an uncle with Tay-Sachs disease. The question is whether or not the man and woman are heterozygotes as they do not have the disease. If both are heterozygotes or carriers then there is a risk of having an affected child. The pedigree looks like this:
Pedigree can be found here: https://www.ncbi.nlm.nih.gov/books/NBK21257/
What is the probability that their first child will have Tay-Sachs (AR)? (show work)
What is the probability that their second child will have Fanconi Anemia?
What is the risk of an affected child if one of the parents is a carrier?
Related textbook solutions
Related questions
In blood typing, Rh+ or the having the Rh factor (R) is dominant over Rh- lacking the Rh factor (r). Can 2 Rh- parents produce an Rh+ child?
| yes | ||
| no, the genetics can't work |
Sickle cell anemia is a recessive disease in humans. If only one parent carries a recessive allele and the other parent is homozygous dominant, what the probability that a child will have sickle cell anemia?
| All or 100% | ||
| 3/4 or 75% | ||
| 1/2 or 50% | ||
| 1/4 or 25% | ||
| none or 0% |
A woman with AB blood type marries a man with B (whose mother had O blood type)? What possible blood types will their children have?
| all AB | ||
| all B | ||
| A and B | ||
| A, B and AB | ||
| AB, A, B and O |
