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Albinism is a recessive autosomal trait causing the complete loss of pigment in affected individuals. Nail-Patella syndrome affects the structure of connective tissue and is a rare dominant autosomal trait. A man with Nail-Patella syndrome marries an apparently normal woman. They have one child who has both albinism and Nail-Patella syndrome. 1) What are the genotypes of the parents? Use standard Mendelian symbols and define each. 2) If these parents have four more children, what is the probability of all four being normal in appearance? Show your calculations.

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Reid Wolff
Reid WolffLv2
29 Sep 2019

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Related questions

A woman, Melanie, and a man, Allan, who are both carriers for phenylketonuria (a rare autosomal recessive disease) have two daughters, Jessica and Andrea, and two sons, Kyle and James. None of Melanie and Allan's parents, or their siblings, had phenylketonuria. However, both of their sons have the disease.
Answer questions 1 to 8 based on this scenario. Please use P to indicate the dominant allele for this condition and p to represent the recessive allele.

1) What are Melanie and Allan's genotypes?

2) Based on the scenario given, what are the most likely genotypes of Melanie's parents and of Allan's parents?

3) What are the genotypes of each of their daughters? What are the genotypes of their sons?

4) What percentage of Melanie's eggs will carry the phenylketonuria allele? What percentage of Allan’s sperm will carry the phenylketonuria allele?

5) Melanie is pregnant and she and Allan have just found out the sex of the fetus is male. What is the probability the fetus is carrying two copies of the recessive phenylketonuria allele, and thus will be affected with the disease?

6) Among Melanie and Allan's four children, how does the observed frequency of affected children compare to the expected frequency? Does the observed result go against the concepts of Mendelian genetics?

1. A person is described as a carrier for a particular genetic disease. What does this tell you about their genotype?

2. For any given gene, the principle of independent segregation predicts that each gamete produced as a result of meiosis will contain ____________________

3. A pair of alleles is said to be heterozygous when:


4. In a diploid species, cells can have up to ___ alleles of a particular gene.

5. In a cross between a homozygous dominant parent and a homozygous recessive parent, the number of phenotypic classes observed in the offspring is ______

6. For a person of genotype Xx, the genotype of their gametes may be ______________

7. In a "test cross", an individual of unknown genotype is crossed with a ___ individual to determine the unknown genotype.

8. An albino woman has a child with a phenotypically normal man with no family history of albinism (which is a rare recessive disorder). What percentage of their children are likely to be albino?

9. An individual with the dominant phenotype, but an unknown genotype, is test-crossed, and all of the offspring exhibit the dominant phenotype. The genotype of the unknown individual is ______________

10. If two heterozygous individuals for a recessive disease (carriers) have a child, what is the chance that their child will develop the disease?

11. In a monohybrid cross between two true-breeding parents that both exhibit the dominant phenotype, ___ percent of the offspring will exhibit the recessive phenotype.

12. In a particular type of tomato plant, red fruit is dominant over yellow fruit, and dwarf height is a recessive trait. If two heterozygous plants were crossed, what proportion of the offspring would show the dominant phenotype?

13. In a cross between a BbRr individual and a BBRR one, what do the following represent: BR, Br, bR, br?

14. In humans, the gene that determines whether an embryo develops as a male or a female is carried on _____________

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