Question

Mr. Smith suffering from renal failure, characterized by a gradual decrease in his kidneys's ability to perform their normal functions. Over the past few months, blood test have indicated an increasing concentration of urea in his blood, which is a sign that the concentration of urea in the extracellular fluid membrane into the toxic waste produced inside cells, diffuses across the plasma membrane into the extracellular fluid. The kidneys eliminate excess urea in the urine. Explain why the extracellular concentration of urea is increasing, and predict how the intracellular concentration of urea is changing.