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INSTRUCTIONS:
-ANSWER EACH QUESTION IN 1 PARAGRAPH. EACH ANSWER CANNOT EXCEED MORE THAN HALF A PAGE.
-PROVIDE TWO REFERENCES FOR EACH ANSWER (NO WIKIPEDIA!). USE A CITATION FORMAT OF YOUR CHOICE AND BE CONSISTENT.

1. (a) Discuss the permeability of biological membranes as a function of hydrophilicity / lipophilicity of solute molecules. (b) Discuss the permeability of biological membranes as a function of a solute molecule size. (c) What is the approximate molecular weight above which the permeation of water-soluble substances by diffusion occurs at negligible rates? (d) How do water-soluble molecules that are much larger than this cut-off enter and leave the cell?


2. The poison cyanide acts by binding irreversibly to one of the components of the electron transport chain, blocking its action. As a result, the entire electron transport process comes to a screeching halt and the cells lose 94% of their ATP-producing capacity. Considering the types of cellular activities that depend on energy expenditure, what would be the consequences of cyanide poisoning?


3. Briefly discuss gene therapy and describe 2 potential clinical applications.

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Casey Durgan
Casey DurganLv2
1 Apr 2018

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