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---------------------------16. The order is to give a medication 0.25 g po four times a day. The medication is available as 150mg /5mL. How many tsp will be given for each dose?

----------------------------17. A bottle of Tagamet tablets is labeled 200mg/tablet. The order is for 400 mg twice a day. The patient will be on this medication for two weeks. How many tablets will be prescribed to ensure he has coverage during this period?

---------------------------18. Order: 1500 mL of NS to be administered over 12 hours. Tubing label states Drop factor: 15gtt/mL. The pump will be set to deliver how many mL per hour?

---------------------------19. Your patient is to receive 1 liter of D5W over the next 8 hours. The tubing is labeled 60 gtt/mL. How many gtt/min will you give?

--------------------20. The patient is to take tetracycline, 0.75 g PO. The medication is available in 250 mg tablets. How many tablets will the patient take per dose?

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----------------------2. Physician Order: DiaBeta 5 mg p.o. Drug Label: DiaBeta tablets 2.5 mg. How many tablets will you give the patient?

------------------------3. Verapamil 2.5mg IV is ordered. The vial contains 5mg/mL. How many mL will be given per dose?

------------------------- 4. The order is for Morphine 8 mg I.M. The drug label reads morphine 10 mg/mL. How many milliliters will the patient receive?

---------------------------5. Order: Fentanyl 50mcg IM. Available is a vial containing 0.05mg/mL. How many mL will be administered?

--------------------------- 6. Dr. orders: give Â½ gm of a med. You have on the shelf 200mg/mL vials. How many mL will you give?

----------------------------7.The order reads 125 mL D5W per hour. The set delivers 10 gtt per mL. How many gtt/min will you administer?

----------------------------8. Your client weighs 75 kg. She is to receive 0.004 mg of Dopamine per Kg of body weight per minute. You are to add 400 mg of Dopamine to 500 mL normal saline. The drip factor of your tubing is 60gtt/mL, how many gtt/min will you deliver?

------------------------ 9. Order 60mg/kg/day in 2 divided doses. Available: 100mg/mL vials. Patient weighs 125lbs. How many mL will you give per dose?

-------------------------10. Order: Lopressor (Metoprolol) 100 mg po, bid. Available: Lopressor, 50 mg tablets. The client is going on a 2-week vacation & must have adequate medication to last him until he returns home. How many tablets will he need to have to cover the time of his vacation?

------------------------- 11. Order: Kanamycin 1.5 gm po q8h x 7 days. Available: Kanamycin 500 mg capsules. How many capsules will the client receive in the 7 days he is to receive this medication?

--------------------------12. Order: Heparin, 600 U (units) SQ daily. Available: 1000 U/mL. How many mL will the patient receive?

--------------------------13. Two liters of IV Lactated Ringer's is ordered to be given over 12 hours. The drop factor is 60gtt/mL. The IV has been running for 8 hours and 700 mL remain. How many gtt/min are needed so

that the IV finishes in the required time?

-------------------------14. The client is receiving a heparin infusion at 20mL/hour. The medication is provided as 25,000 units in 500mL of D5W. How many units of heparin will the client receive during a 8-

hour shift?

--------------------------15. Order: Give 500mg of Keflex po q4 hr. Available: 250 mg tablets. How manytablets will the patient receive in a 24-hour period?

---------------------------16. The order is to give a medication 0.25 g po four times a day. The medication is available as 150mg /5mL. How many tsp will be given for each dose?

----------------------------17. A bottle of Tagamet tablets is labeled 200mg/tablet. The order is for 400 mg twice a day. The patient will be on this medication for two weeks. How many tablets will be prescribed to ensure he has coverage during this period?

---------------------------18. Order: 1500 mL of NS to be administered over 12 hours. Tubing label states Drop factor: 15gtt/mL. The pump will be set to deliver how many mL per hour?

---------------------------19. Your patient is to receive 1 liter of D5W over the next 8 hours. The tubing is labeled 60 gtt/mL. How many gtt/min will you give?

--------------------20. The patient is to take tetracycline, 0.75 g PO. The medication is available in 250 mg tablets. How many tablets will the patient take per dose?

12) Medical Related Math problems

(A)

Donald is a 50 year old male with a long history of bipolar disorder. He has been hospitalized three times in the last 8 months for manic episodes. He was just admitted to your impatient psychiatric ward because he was trying to get though the security gate at the Southwest Airlines terminal, demanding to catch a flight to the moon. As the polic approached him he started to take of his clothes and urinate on the floor. They could not understand him because he was talking and yelling very fast. His urine toxicology screen is positive for marijuana and his admission labs including liver function tests are normal. He clearly appears manic so you decide to start a mood stabilizer, Depakote in combination with an atypical anti-psychotic, Olanzapine. Itâs your first year as a psychiatry resident and you remember that Depakote is prescribed according to a patientâs weight. Donald weighs 90 kg and you want to treat aggressively at 30 mg/kg/day. All daily dosages greater than 250 mg should be given either twice a day or three time a day. You want to keep it as simple for the patient as possible so you decide to give it twice a day, once in the morning and once at bedtime. If you divide the doses equally, what are his morning and bedtime doses?

(B)

A cat has just arrived to the veterinary clinic with low blood pressure. The cat weighs 5 kg, and as the on call Vet you want to use a bag of saline to prepare a dopamine drip for the cat. Based on the catâs weight you want it to receive 5 ml/hour of drip that has a concentration of 0.3mg/ml. You also want the cat to receive the drip for at least 48 hours so you need to prepare 250 ml of the dopamine drip. How much dopamine do you need to add from a stock concentration of dopamine (200mg/5ml) to a final volume of 250 ml of saline?

sapphireguinea-pig180

1) The neurotransmitters acetylcholine and norepinephrine are digested by enzymes that are located at the axon synapse or within the axon terminal of the neurons.

a)What are the names of these different types of enzymes?

b)Where are they located and what is the result of their enzymatic activity?

2) Explain how the Investigational New Drug process works as well as the four different phases of clinical trials. Why are some drugs still taken off the market after approval by the FDA?

3) A single IV injection of 100 mg drug with a half-life of 4 hours is administered to a young adult.

a) Plot drug concentration versus time on a graph making certain to clearly label.

b) How long will it take to eliminate > 95% of the drug?

c) If the volume of distribution is 4L, what is the clearance of the drug?

4) Many drugs are metabolized in the liver through the microsomal metabolizing system.

a) What specific enzymes are involved in this metabolism?

b) What are the main functions of these enzymes?

c) What are some factors that can contribute to individual drug metabolism variation? Explain.

5) Think of an emergency situation requiring immediate and intense physical exertion.

a) List as many body organs as you can and predict the desired level of activity [increased or decreased].

b) Which neurotransmitter would produce these effects and through what receptors?

6) It is interesting that a drug can produce a therapeutic effect and an undesired side effect in one situation, and that the same drug side effect may be considered a therapeutic effect in another situation. Explain this phenomenon using the drug promethazine as an example.

7) A patient brought into the emergency room is experiencing severe hypotension. Blood pressure reads 90/50.

a) What class of drugs is indicated for treatment and why?

b) What precautions should be observed when these drugs are administered?

c) What would be the first indication that too much drug has been administered?

8) Only certain drugs are capable of crossing the blood brain barrier.

a) How is the blood brain barrier different than barriers found in other areas of the body? Be specific.

b) What properties of drugs will make it more likely to cross the blood brain barrier? Explain your answers.

9) A 32-year-old, presents to the Emergency Department by ambulance with vomiting, confusion, salivation, and respiratory distress. The patient states that he was feeling fine until today when I started getting ill. He then vomits. During a physical exam you record the following information: Heart rate 45; Blood pressure 90/60; Respiratory rate 25; Temperature 36.6C; Pupils constricted. During your exam, 4 more ambulances arrive with patients with similar symptoms. You find out they were all riding in the same care on the Red Line when they began feeling ill.

a) What do you feel is happening and why?

b) Would you expect their symptoms to improve over time? Why or why not?

c) What drug would you prescribe to treat these patients and why?

10) Betty has diabetes and asthma. She also has developed high blood pressure, for which doctor just prescribed propranolol. One of your duties as a physicianâs assistant is to make sure patients are not prescribed drugs that are contraindicated because of other health problems.

a) What should you tell the doctor about Bettyâs prescription for propranolol and why?

b) Is there a more appropriate drug for Betty? Explain you answer.

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