Explain how molecular markers and the concept of linkage are used to determine the approximate genomic location of disease-causing mutations.
Explain how molecular markers and the concept of linkage are used to determine the approximate genomic location of disease-causing mutations.
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Q.) A geneticist is mapping the location of three markers relative to a disease causing genetic variant. Her results are shown below. Based on the results of the mapping, answer the following questions.
Marker | Recombination fraction relative to disease gene |
X | 0.3 |
Y | 0.5 |
Z | 0.1 |
a.) Which marker is closest to the disease-causing genetic variant? Support your answer. (2)
b.) Which marker is not linked to the disease-causing variant? Support your answer. (2)
c.) If the geneticist scored 200 chromosomes for recombination, how many recombinants did she observe for each marker? (2)