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8 Feb 2019

Instructions: Select 2 potential antidotes only from those listed in the box at the bottom.

More than 2 correct answers are possible. For credit you must submit this in class on TUES., Feb. 21 See the 2 sample answers for atropine & physostigmine.

POISON Mode of Action ANTIDOTE

Select 2 from those listed in the box below!

Atropine blocks neurotransmitter (2), (6)

(from belladonna) acetylcholine binding to

post-synaptic receptors

Nicotine mimics the action of acetylcholine

(from tobacco) in NMJ

Physostigmine inhibitor of acetylcholinesterase (4), (5)

(in calabar bean) (in NMJ)

Botulinum Toxin [Botox] blocks vesicles from releasing

(causes botulism) acetylcholine into NMJ

Digoxin inhibitor of Na⁺/K⁺ ATPase

(cardiac medication) pump in axon membrane

Black widow venom enhances release of acetylcholine into NMJ

(latrotoxin) by synaptic vesicles

Pufferfish toxin blocks closed Na⁺ gates of axon

(tetrodotoxin)

NMJ = neuromuscular junction (synapse between neuron & muscle cell)

POTENTIAL ANTIDOTES:

(1) atropine; (2) nicotine; (3) physostigmine; (4) botulinum toxin;

(5) digoxin; (6) black widow venom; (7) pufferfish toxin

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11 Feb 2019

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