Please explain (in your own words) the difference between the mutation accumulation hypothesis and the antagonistic pleiotrophy hypothesis.

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Jarrod RobelLv2

15 Dec 2018

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Answer all question please. Don't copy and paste use your own words. Don't use handwriting,please I need Reference link . (important)

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Answer all question please. Don't copy and paste use your own words. Don't use handwriting,please I need Reference link . (important)

Book: Introduction to Biostatistics

Q2: What are dependent and independent variables in research?
Q3: What is the difference between a research question and a research hypothesis?

The e4 allele of apolioprotein (APOE) increases the probability of developing Alzheimer disease (AD). How e4 does this is not known. Your hypothesis is that the e4 allele prevents the repair of small brain injuries, and that this causes an accumulation of unrepaired small brain injuries, injuries individuals with normal APOE alleles repair, and that AD symptoms result from the accumulation of these unrepaired injuries. You want to do a study of the US population to test your hypothesis.

a. Briefly describe the study you want to do, and explain how this study will test your hypothesis.

b. Predict what results you would find if the hypothesis is correct.

c. Explain to the research funding board why you think these results would be convincing evidence that your e4 hypothesis is correct.

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Please explain (in your own words) the difference between the mutation accumulation hypothesis and the antagonistic pleiotrophy hypothesis.

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