What are some extensive experiment procedures that can be done to test the efficacy of the drug Aricept. List at least 4 and explain the reasoning why you chose this method for each
What are some extensive experiment procedures that can be done to test the efficacy of the drug Aricept. List at least 4 and explain the reasoning why you chose this method for each
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QUESTION 1
A partial agonist would:
a) Have lower efficacy than a full agonist | ||
b) Would be less effective at stabilizing the active form of a receptor than a full agonist | ||
c) Would have greater intrinsic activity than an antagonist | ||
d) All of the above |
QUESTION 2
The presence of spare receptors means that a drug would:
a) Would have its potency unchanged by low levels of noncompetitive antagonists | ||
b) Still maintain its maximal efficacy at low concentrations of noncompetitive antagonists | ||
c) Achieve its maximal response without occupying all available receptors | ||
d) A and C | ||
e) B and C |
QUESTION 3
A competitive antagonist would:
a) Increase drug potency | ||
b) Decrease drug efficacy | ||
c) Decrease drug potency | ||
d) Increase drug efficacy |
QUESTION 4
pH trapping explains:
a) Why drugs will break down when exposed to acidic conditions | ||
b) Why drugs do not diffuse back and forth between the kidneys and circulation | ||
c) Why drugs are attracted to adipose tissue | ||
d) How drugs are metabolized |
QUESTION 5
An ideal drug would have:
a) High potency, high efficacy, and a large therapeutic index | ||
b) High potency, high efficacy, and a small therapeutic index | ||
c) A high ED50, high efficacy, and a large therapeutic index | ||
d) High intrinsic activity, low affinity, and a low LD50 |
QUESTION 6
Which of the following is most likely to cross the membrane of a cell?
a) A nonpolar compound | ||
b) A polar compound | ||
c) A charged compound | ||
d) A large compound |
QUESTION 7
Which is not a pharmacodynamic process?
a) Absorption | ||
b) Excretion | ||
c) Metabolism | ||
d) Digestion |
QUESTION 8
A drug with a low Vd would:
a) Be less likely to bind to plasma proteins | ||
b) Have a higher rate of clearance | ||
c) Disseminate widely through tissues | ||
d) Remain primarily within the circulation |
QUESTION 9
First-pass metabolism does not occur through which method of drug administration?
a) Intramuscular | ||
b) Intravenous | ||
c) Transdermal | ||
d) Enteral |
QUESTION 10
A drug with greater efficacy would:
a) Have a greater maximal response | ||
b) Require a lower dose to reach its maximal effect | ||
c) Be less toxic | ||
d) All of the above |