Describe the role of nucleoside hydrolysis in actin polymerization

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Tod ThielLv2

14 Aug 2018

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Decide whether each of the following statements are true orfalse and explain why.

A. The structural polarity of all microtubules is such thatÃÂ±-tubulin is exposed at one end and ÃÂ²-tubulin is exposed at theopposite end.

B. The role of ATP hydrolysis in actin polymerization is similarto the role of GTP hydrolysis in tubulin polymerization: both serveto weaken bonds in the polymer and thereby promotedepolymerization.

C. All microtubule organizing centers contain centrioles thathelp nucleate microtubule polymerization.

D. All proteins that bind to the ends of microtubules or actinfilaments cap the ends to prevent futher polymerization.

E. In most animal cells, minus end-directed microtubule motorsdeliver their cargo to the periphery of the cell, whereas plusend-directed microtubule motors deliver their cargo to the interiorof the cell.

F. Cadherins promote cell-cell interactions by binding tocadherin molecules of the same or closely related subtype onadjacent cells.

Lots of points offered. Please help.

burgundyserval350

How does the binding of ADP vs. ATP (actin) affect the polymerization / depolymerization rates of actin filaments? Describe how this unequal rate of addition vs. loss of monomers from the filament strands leads to treadmilling in actin filaments

carminemouse503

Cytochalasin is a drug that caps actin filament plus ends, thus preventing actin polymerization. Phalloidin is a drug that binds to and stabilizes actin filaments, preventing actin depolymerization. Even though these drugs have opposite effects on actin polymerization, the addition of either of these drugs instantaneously freezes the cell movements that depends on actin filaments. Explain why drugs that have opposite effects on actin filaments can have a similar effect on cell movements.