2.Describe how nucleosome structure can be modified in eukaryotes, including

methylation, acetylation, and phosphorylation

Okay can anyone help me with this please I am trying to study for my exam. I would greatly appericate the help!!

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Nestor RutherfordLv2

27 Apr 2019

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I am reviewing this article for a biochemistry presentation and need help understanding it. http://www.jbc.org/content/289/27/18707.full?sid=dd97d7e5-e294-4704-bcd6-b2bef3f37b34#cited-by

My question is what background information is going to be necessarry/important for my audience (fellow biochemistry students) to understand what I'm talking about? So far I've explained that epigenetics is the study of changes in gene expression (no change in DNA sequence from these changes), THC acts on CB1 and CB2 receptors which are GPCRs, and CB2 receptors are found on immune cells. I also plan on including that methylation generally results in genes not being expressed and that THC causes Th1 cytokine genes to be suppressed and Th2 genes to be expressed, resulting in anti-inflammatory effects. Please correct me if this is wrong. I also plan to explain what cytokines and histones are. Anything else you may think would be helpful is greatly appreciated. Thank you