Enzymes use several types of catalytic mechanisms. Differentiate between acid-base catalysis, covalent catalysis, and metal ion catalysis. (If you answer any part of this question incorrectly, a single red X will appear indicating that one or more of the phrases are sorted incorrectly.) Acid-base catalysis Covalent catalysis Metal ion catalysis All catalysts may participate in oxidation-reduction reactions by changes in the oxidation state a Zn2+ cofactor may properly orient the substrate in the active site through ionic interactions may take part in interactions involving Fe2+ lowers the energy or stabilizes the transition state or intermediate catalyst retains its original form after reaction occurs a proton is transferred between enzyme and substrate a covalent bond forms between enzyme and substrate two-part catalytic process (for example, the chymotrypsin mechanism) use a nucleophilic function group may use amino acids such as aspartate or lysine for protonation or proton abstraction